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| Time Line |
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| 1452 | 15 April: Born at Anchiano, near Vinci, Tuscany | |
| 1469 | Probably moves to Florence and enters the studio of Verrocchio | |
| 1472 | Member of the Company of St. Luke, Florence | |
| ca. 1473-76 | Annunciation, Madonna with the carnation, Ginevra de' Benci | |
| 1476 | Still in Verrocchio's Studio | |
| 1478 | January: Commission for altarpiece for Palazzo della Signoria | |
| ca. 1478 | Benois Madonna | |
| 1481 | March: Commission for Adoration of Magi September: Last payment for Adoration of Magi |
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| ca. 1482 | St. Jerome. Moves to Milan | |
| 1483 | April: Commission for Virgin of the Rocks | |
| ca. 1483-89 | Enters service of Ludovico Sforza. Cecilia Gallerani, Portrait of a musician, Louvre Virgin of the Rocks | |
| 1487-90 | Architectureal work in Milan and Pavia. First anatomical studies | |
| ca. 1489-93 | At work on Sforza monument | |
| ca. 1494-97 | At work on the Last Supper; probably begins London version of the Virgin of the Rocks | |
| 1498 | Murals in Sala della Asse, Castello Sforzesco, Milan | |
| 1499 | December: Leaves Milan | |
| 1500 | February: In Mantua. Protrait of Isabella d'Este | |
| 1501 | April: At work on Madonna of the Yarnwinder and a cartoon of Madonna and Child with St Anne | |
| 1502-03 | Architect, engineer and mapmaker to Cesare Borgia | |
| 1503 | October: Begins cartoon of the Battle of Anghiari | |
| 1504-05 | At work on Battle of Anghiari; probably designed Leda and Mona Lisa | |
| 1505 | Studies of birdflight and geometry | |
| 1506-07 | Travelling repeatedly between Florence and Milan | |
| 1507-08 | Winter: Dissection of centenarian in S. Maria Nuova, Florence | |
| 1508 | Easter: Returns to Milan, in service of Louis XII | |
| 1508-13 | Studies of anatomy and water. Designs for Trivulzio monument. Probably begins panel of Madonna and Child with St Anne |
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| 1513 | September: Leaves Milan December: In Rome, in the service of Giuliano de, Medici |
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| 1514-16 | Possibly at work on Madonna and Child with St. Anne, Mona Lisa, Leda, St John the Baptist | |
| 1515 | In Florence. Studies for new Medici Palace | |
| 1516 | August: Last record in Rome | |
| 1517 | January: At Romorantin, France | |
| 1517-19 | In service of Francis I. Right hand paralysed. Architectural and geometrical studies. Designed for masquerades and equestrian monument. Assistants working on Madonna and Child with St. Anne | |
| 1519 | 2 May: Dies at Amboise | |
| (Clayton 7) | ||